Monthly
$179
/mo
Flexibility with month-to-month billing.
- Compounded KPV therapy
- Licensed clinician oversight
- Care-team messaging
- Free discreet shipping
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KPV Inflammatory Support Therapy
KPV is a tripeptide derived from alpha-MSH and studied for its potential anti-inflammatory properties. Truvera’s KPV Therapy is designed to support immune balance and overall wellness.
Potential Benefits
- Supports immune and inflammatory balance
- Encourages gut and skin health
- Promotes overall well-being
Short Version
A peptide therapy designed to support inflammatory balance and immune health.
- US-licensed clinicians
- Licensed US pharmacies
- Prescription required
- Free discreet shipping
Peptide · Inflammatory Support
Calm the inflammation driving your symptoms — from the inside out.
KPV is a naturally occurring tripeptide derived from alpha-MSH, studied for its ability to quiet the NF-kB signaling pathway at the root of chronic inflammatory conditions. Prescribed by a licensed clinician, compounded to order, and shipped to your door.
- Targets NF-kB, a master regulator of pro-inflammatory cytokines including TNF-a, IL-1b, and IL-6
- Studied in gut, skin, and wound-healing applications with a favorable tolerability profile
- Derived from a naturally occurring hormone — does not suppress immune function like steroids
How it works
Your KPV therapy journey in 4 steps
From online intake to medication delivered — in as little as 3 days.
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Complete your online intake
A 5-minute medical intake covers your health history, current symptoms, medications, and inflammatory goals. No appointment needed.
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Clinician review
A licensed US clinician reviews your intake and, if clinically appropriate, issues your KPV prescription and compounding order.
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Medication ships free
Your KPV is compounded at a licensed US pharmacy and shipped in discreet, temperature-controlled packaging.
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Ongoing care
Message your care team anytime. We monitor your response and adjust your protocol at every check-in.
Pricing
Transparent KPV program pricing.
One monthly price covers your clinician visits, compounded medication, shipping, and care team access.
Most popular
Quarterly
$149
/mo
Save 17% vs monthly
Best balance of savings and commitment.
- Everything in Monthly
- Billed quarterly
- Priority clinician response
- Quarterly symptom review
Annual
$129
/mo
Save 28% vs monthly
Our best price for long-term inflammatory support.
- Everything in Quarterly
- Billed annually
- Dedicated care coordination
- Annual protocol review
KPV is a compounded peptide, not an FDA-approved drug. Prescriptions are issued only at the discretion of licensed clinicians and only when medically appropriate.
Eligibility
Is KPV right for you?
You may be a candidate if:
- You have a chronic inflammatory condition such as IBD, IBS, psoriasis, eczema, or rosacea
- You've found conventional anti-inflammatories insufficient or want to reduce steroid dependence
- You are 18+ and can complete required intake and follow-up monitoring
- You are seeking a clinician-supervised peptide approach to inflammatory support
Not right for you if:
- You are pregnant, trying to conceive, or breastfeeding
- You have a current or prior cancer diagnosis (clinician review required)
- You have an active, untreated systemic infection
- You take immunosuppressant medications without clearance from your prescribing physician
What is KPV?
The science behind KPV.
KPV is a tripeptide — three amino acids (lysine, proline, valine) — representing the active C-terminal fragment of alpha-melanocyte-stimulating hormone (alpha-MSH), a naturally occurring peptide produced in the body. Researchers identified that this short sequence retains the powerful anti-inflammatory properties of its parent hormone while shedding the pigmentation and appetite-related effects. Its primary mechanism involves inhibiting NF-kB, a transcription factor that acts as a master switch for pro-inflammatory gene expression, reducing downstream cytokines including TNF-a, IL-1b, and IL-6.
Preclinical research, including studies published in Gastroenterology, has examined KPV in models of inflammatory bowel disease, skin inflammation, and wound healing. In gut applications, KPV is transported into intestinal cells via the PepT1 transporter — a pathway upregulated during active IBD — where it can accumulate and dampen inflammatory signaling directly. KPV has not yet completed human clinical trials and is not FDA-approved as a standalone drug. It is available through licensed clinicians via Section 503A compounding pharmacies.
Patient experience
Care that feels clear from day one.
"I've dealt with gut inflammation for years — every flare was unpredictable. After two months on KPV I've had my longest stretch without symptoms. The intake was easy and my clinician actually explained the science."
Verified patient
Inflammatory support
"My dermatologist couldn't get my skin under control. Within six weeks the redness and flares were noticeably calmer. No side effects I could detect."
Verified patient
Skin health
"I appreciated that TruVera was upfront that this is a compounded peptide, not a magic pill. The care team checked in consistently and my inflammatory markers improved on my last labs."
Verified patient
Care team support
FAQ
KPV therapy questions
What exactly is KPV and is it FDA-approved?
KPV is a tripeptide (lysine-proline-valine) derived from alpha-melanocyte-stimulating hormone, studied for anti-inflammatory properties. It is not FDA-approved as a standalone drug. TruVera provides KPV through licensed compounding pharmacies under Section 503A of the Federal Food, Drug, and Cosmetic Act — available only with a valid prescription from a licensed clinician.
What conditions is KPV used for?
Clinical interest in KPV centers on chronic inflammatory conditions including inflammatory bowel disease (Crohn's, ulcerative colitis), irritable bowel syndrome, inflammatory skin conditions (psoriasis, eczema, rosacea, acne), and general systemic inflammation. It has also been studied in wound healing and tissue repair contexts. A clinician will determine whether KPV is appropriate for your specific situation.
How is KPV taken?
KPV can be compounded in several forms depending on your clinical needs: oral capsules (most common for gut-focused applications), subcutaneous injection (for systemic effects), or topical formulation (for skin conditions). Your care team will specify the dose and route during your consultation.
How long before I notice results?
Some patients report improvements within 3–7 days; more significant changes are typically observed over 4–8 weeks of consistent use. Peptide therapy responses vary considerably by individual, baseline inflammation level, and indication. Your clinician will evaluate your progress at regular check-ins.
Are there side effects?
KPV has a favorable tolerability profile in preclinical studies, without the immune-suppressing effects of corticosteroids. Reported mild effects include temporary injection-site reactions (for injectable formulations) and brief digestive adjustment for oral capsules. Long-term human safety data is limited given the absence of completed clinical trials. Your clinician will review your full health history before prescribing.
Can I pause or cancel my subscription?
Yes. You can pause or cancel at any time through your TruVera patient portal — no phone calls, no cancellation fees. If you have questions about your protocol before canceling, your care team is always available to discuss adjustments.