Monthly
$179
/mo
Flexibility with month-to-month billing.
- Compounded Semax therapy
- Licensed clinician oversight
- Care-team messaging
- Free discreet shipping
Skip to product information
Start today
Semax Cognitive Therapy
Semax is a nootropic peptide studied for its potential to support cognitive function, focus, and mental clarity. Truvera’s Semax Cognitive Therapy offers a physician-guided approach for individuals seeking enhanced productivity and neurological support.
Potential Benefits
- Supports focus and mental clarity
- Enhances cognitive performance
- Promotes stress resilience
- Encourages overall brain health
Short Version
Physician-guided nootropic peptide therapy designed to enhance focus and cognitive performance.
- US-licensed clinicians
- Licensed US pharmacies
- Prescription required
- Free discreet shipping
Neuropeptide · Cognitive Therapy
Sharpen focus, protect your brain, and build cognitive resilience — from the inside out.
Semax is a synthetic heptapeptide analog of ACTH(4-7), engineered to promote BDNF production and neuroprotection without adrenal stimulation. Prescribed by a licensed clinician, compounded to order, and shipped to your door.
- Upregulates BDNF and activates a neurotrophin cascade that supports neuroplasticity, synaptic strength, and long-term memory consolidation
- Intranasal delivery crosses the blood-brain barrier rapidly via olfactory pathways, enabling direct CNS uptake without first-pass hepatic metabolism
- Developed at Russia's Institute of Molecular Genetics and approved in Russia for stroke recovery and cognitive impairment; available in the US via 503A compounding
How it works
Your Semax therapy journey in 4 steps
From online intake to medication delivered — in as little as 3 days.
-
Complete your online intake
A 5-minute medical intake covers your health history, current cognitive symptoms, medications, and cognitive performance goals. No appointment needed.
-
Clinician review
A licensed US clinician reviews your intake and, if clinically appropriate, issues your Semax prescription and compounding order.
-
Medication ships free
Your Semax is compounded at a licensed US pharmacy and shipped in discreet, temperature-controlled packaging.
-
Ongoing care
Message your care team anytime. We monitor your cognitive response and adjust your protocol at every check-in.
Pricing
Transparent Semax program pricing.
One monthly price covers your clinician visits, compounded medication, shipping, and care team access.
Most popular
Quarterly
$149
/mo
Save 17% vs monthly
Best balance of savings and commitment.
- Everything in Monthly
- Billed quarterly
- Priority clinician response
- Quarterly cognitive review
Annual
$129
/mo
Save 28% vs monthly
Our best price for long-term cognitive support.
- Everything in Quarterly
- Billed annually
- Dedicated care coordination
- Annual protocol review
Semax is a compounded neuropeptide, not an FDA-approved drug in the United States. Prescriptions are issued only at the discretion of licensed clinicians and only when medically appropriate.
Eligibility
Is Semax right for you?
You may be a candidate if:
- You experience brain fog, mental fatigue, or difficulty staying sharp throughout the day
- You have difficulty concentrating or retaining information and want clinician-supported intervention
- You have cognitive performance goals — academic, professional, or athletic — and want neuropeptide support
- You are seeking neuroprotective support to preserve and strengthen long-term cognitive resilience
Not right for you if:
- You are pregnant, trying to conceive, or breastfeeding
- You have an active seizure disorder without neurologist clearance
- You take psychiatric medications that may interact with dopaminergic or serotonergic modulation (clinician review required)
- You are under 18 years of age
What is Semax?
The science behind Semax.
Semax is a synthetic heptapeptide analog of ACTH(4-7) — the behaviorally active fragment of adrenocorticotropic hormone — developed in the 1980s at Russia's Institute of Molecular Genetics under the direction of academician Nikolai Myasoedov. The original goal was to preserve the nootropic and neuroprotective properties of ACTH while eliminating its adrenal and steroidogenic effects. By isolating and extending the ACTH(4-7) core sequence with a Pro-Gly-Pro C-terminal addition, researchers created a molecule that engages central nervous system targets without activating the hypothalamic-pituitary-adrenal axis.
Semax's most studied mechanism is upregulation of brain-derived neurotrophic factor (BDNF) and its receptor TrkB, along with broader neurotrophin signaling including nerve growth factor (NGF). BDNF is central to synaptic plasticity, long-term potentiation, and neuronal survival — making its upregulation a key target for cognitive enhancement and neuroprotection. Semax also modulates dopaminergic and serotonergic transmission, contributing to improvements in attention, motivation, and mood tone observed in clinical use. In ischemia models, Semax has demonstrated robust neuroprotective effects by reducing neuronal apoptosis and inflammatory cytokine expression following hypoxic injury — the mechanistic basis for its approved use in Russia for stroke and transient ischemic attack.
In Russia, Semax holds regulatory approval and is used clinically for stroke recovery, cognitive impairment, and optic nerve disease. It is not approved by the FDA in the United States, but is available through licensed 503A compounding pharmacies with a valid prescription. Intranasal administration is the standard route: nasal mucosa allows direct peptide transport along olfactory nerve pathways into the CNS, bypassing first-pass hepatic metabolism and achieving rapid central bioavailability. TruVera's Semax is compounded to order at licensed US pharmacies and dispensed only following clinician review and prescription.
Patient experience
Care that feels clear from day one.
"I've struggled with focus my entire adult life and was skeptical about peptides. Three weeks into Semax I noticed I could hold a train of thought through a full work block — something that used to take serious effort. The intake was fast and my clinician was thorough about explaining what to expect."
Verified patient
Cognitive performance
"The mental clarity I get from Semax is unlike anything I've tried before. Brain fog that I'd accepted as baseline just lifted. My memory for details at work is noticeably sharper and I feel less mentally drained at the end of the day."
Verified patient
Mental clarity
"I started Semax to recover cognitively after a period of burnout. The difference in my ability to process information quickly and retain what I read has been significant. TruVera's care team checked in regularly and adjusted my protocol when I had questions."
Verified patient
Work performance
FAQ
Semax therapy questions
What is Semax and is it FDA-approved?
Semax is a synthetic heptapeptide analog of ACTH(4-7), engineered to deliver the nootropic and neuroprotective effects of adrenocorticotropic hormone without adrenal stimulation. It was developed at Russia's Institute of Molecular Genetics and holds regulatory approval in Russia for use in stroke, transient ischemic attack, and cognitive impairment. It is not FDA-approved in the United States. TruVera provides Semax through licensed compounding pharmacies under Section 503A of the Federal Food, Drug, and Cosmetic Act — available only with a valid prescription from a licensed US clinician.
What cognitive effects can I expect from Semax?
Patients and clinical users commonly report improvements in sustained attention, working memory, information processing speed, and mental stamina. Semax's upregulation of BDNF supports synaptic plasticity and long-term memory consolidation, while its dopaminergic and serotonergic modulation contributes to improved motivation and mood tone. Neuroprotective effects may also help maintain cognitive function under stress or following neurological insult. Individual responses vary; a clinician will evaluate your specific goals and baseline before prescribing.
How is Semax taken?
Semax is administered intranasally — typically as drops applied to the nasal mucosa 2–3 times daily. This route allows the peptide to travel along olfactory nerve pathways directly into the central nervous system, bypassing the liver and achieving rapid CNS uptake. Your clinician will specify your exact dose, concentration, and dosing schedule based on your intake and cognitive goals.
How long before I notice results?
Some patients report increased mental clarity and focus within 1–2 weeks of starting Semax; more substantial cognitive improvements — including enhanced memory and reduced brain fog — are typically observed after 3–4 weeks of consistent use. Neuroprotective and neuroplasticity-related benefits tend to accumulate over longer treatment periods. Your clinician will assess your progress at regular check-ins and adjust the protocol as needed.
Are there side effects?
Semax is generally well tolerated. The most commonly reported effects are mild nasal irritation or transient discomfort at the site of intranasal administration. Some users report mild fatigue during the first few days as the body adjusts. At higher doses, anxiety or heightened arousal has been noted in some individuals — a reason why clinician oversight and appropriate dosing are important. Long-term safety data from large-scale human trials in the US is limited. Your clinician will review your full health history, medications, and any potential interactions before issuing a prescription.
Can I pause or cancel my subscription?
Yes. You can pause or cancel at any time through your TruVera patient portal — no phone calls, no cancellation fees. If you have questions about your protocol or want to discuss adjusting your dose before canceling, your care team is always available to help.