Monthly
$199
/mo
Flexibility with month-to-month billing.
- Compounded Dihexa therapy
- Licensed clinician oversight
- Care-team messaging
- Free discreet shipping
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Dihexa Neuro-Optimization Therapy
Dihexa is a peptide studied for its potential neurotrophic properties and cognitive support. Truvera’s Dihexa Neuro-Optimization Therapy is tailored for individuals seeking advanced brain health and memory support.
Potential Benefits
- Supports memory and learning
- Enhances cognitive resilience
- Promotes neurological health
- Encourages mental clarity
Short Version
Advanced neuro-support peptide therapy designed to enhance memory and cognitive function.
- US-licensed clinicians
- Licensed US pharmacies
- Prescription required
- Free discreet shipping
Peptide · Neuro Optimization
Support the synaptic connections that drive memory, focus, and cognitive clarity.
Dihexa is a nootropic peptide derived from angiotensin IV that acts on the HGF/c-Met pathway to drive synaptogenesis — the biological process of building new neural connections. Prescribed by a licensed clinician, compounded to order, and shipped to your door.
- Acts on the HGF/c-Met signaling axis to promote synaptogenesis — the formation of new synaptic connections between neurons
- Studied in preclinical models of cognitive decline, including Alzheimer's disease, with effects on learning and memory
- Derived from angiotensin IV; demonstrates a neuroprotective profile with high CNS penetrance and potency exceeding BDNF in some assays
How it works
Your Dihexa therapy journey in 4 steps
From online intake to medication delivered — in as little as 3 days.
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Complete your online intake
A 5-minute medical intake covers your health history, current symptoms, medications, and cognitive goals. No appointment needed.
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Clinician review
A licensed US clinician reviews your intake and, if clinically appropriate, issues your Dihexa prescription and compounding order.
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Medication ships free
Your Dihexa is compounded at a licensed US pharmacy and shipped in discreet, temperature-controlled packaging.
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Ongoing care
Message your care team anytime. We monitor your cognitive response and adjust your protocol at every check-in.
Pricing
Transparent Dihexa program pricing.
One monthly price covers your clinician visits, compounded medication, shipping, and care team access.
Most popular
Quarterly
$169
/mo
Save 15% vs monthly
Best balance of savings and commitment.
- Everything in Monthly
- Billed quarterly
- Priority clinician response
- Quarterly cognitive review
Annual
$149
/mo
Save 25% vs monthly
Our best price for long-term neuro optimization support.
- Everything in Quarterly
- Billed annually
- Dedicated care coordination
- Annual protocol review
Dihexa is a compounded peptide, not an FDA-approved drug. Prescriptions are issued only at the discretion of licensed clinicians and only when medically appropriate.
Eligibility
Is Dihexa right for you?
You may be a candidate if:
- You have concerns about cognitive decline, memory loss, or early neurodegeneration
- You experience persistent brain fog, difficulty concentrating, or focus issues affecting daily function
- You are 18+ and can complete required intake and follow-up monitoring
- You are seeking a clinician-supervised peptide approach to cognitive support
Not right for you if:
- You are currently taking psychiatric medications with potential interaction concerns (clinician review required)
- You are pregnant, trying to conceive, or breastfeeding
- You have a history of certain cancers where HGF/c-Met pathway activation may be contraindicated
- You have uncontrolled cardiovascular disease
What is Dihexa?
The science behind Dihexa.
Dihexa is a nootropic peptide derived from angiotensin IV, an endogenous fragment of the renin-angiotensin system. Researchers at Washington State University identified that Dihexa acts as a potent agonist of the hepatocyte growth factor (HGF) receptor c-Met — a receptor tyrosine kinase pathway with well-established roles in cell survival, migration, and, critically, synaptogenesis. Synaptogenesis is the biological process by which neurons form new synaptic connections, a mechanism central to learning, memory consolidation, and recovery from neurological injury. By amplifying HGF/c-Met signaling, Dihexa promotes the formation of new dendritic spines and synaptic contacts in regions of the brain responsible for cognition.
Preclinical data from Alzheimer's disease and cognitive-aging models have shown Dihexa to be extraordinarily potent relative to other neurotrophic agents — estimated to be several orders of magnitude more potent than brain-derived neurotrophic factor (BDNF) at driving synaptogenesis in some assays. These findings have generated significant scientific interest in its potential as a cognitive support agent, particularly in contexts of synaptic loss associated with aging and neurodegeneration. It is important to note that Dihexa has not completed human clinical trials and is not FDA-approved as a pharmaceutical drug. Published evidence is primarily preclinical, and results in humans remain under investigation.
Because of its HGF/c-Met mechanism, Dihexa carries theoretical considerations for individuals with cancer histories, as c-Met is also implicated in certain oncogenic processes — a factor that licensed clinicians carefully weigh during the intake and prescribing process. At TruVera, Dihexa is available exclusively through licensed 503A compounding pharmacies, dispensed only with a valid prescription from a clinician who has reviewed your complete health history.
Patient experience
Care that feels clear from day one.
"I noticed a meaningful shift in my mental clarity within the first few weeks. Words I'd been searching for came faster, tasks that used to feel foggy felt organized. My clinician was thorough and checked in regularly."
Verified patient
Mental clarity
"I've tried multiple nootropic stacks over the years with mixed results. Dihexa through TruVera was different — the cognitive sharpness was more consistent and felt more like my brain working properly rather than a stimulant push."
Verified patient
Cognitive sharpness
"What I appreciated most was the transparency. The care team was upfront about the preclinical evidence, didn't over-promise, and the clinician tailored the protocol to my history. That level of medical integrity matters to me."
Verified patient
Care team quality
FAQ
Dihexa therapy questions
What exactly is Dihexa and is it FDA-approved?
Dihexa is a synthetic nootropic peptide derived from angiotensin IV that acts as an agonist of the HGF/c-Met receptor pathway, promoting synaptogenesis and cognitive function. It is not FDA-approved as a standalone drug. TruVera provides Dihexa through licensed compounding pharmacies under Section 503A of the Federal Food, Drug, and Cosmetic Act — available only with a valid prescription from a licensed clinician.
What cognitive benefits can I expect?
Dihexa is primarily studied for its ability to drive synaptogenesis — the formation of new synaptic connections — which supports learning, memory consolidation, and processing speed. Patients and research subjects have reported improvements in memory recall, mental clarity, and sustained focus. Results vary by individual, baseline cognitive status, and protocol adherence. A licensed clinician will discuss realistic expectations during your consultation.
How is Dihexa taken?
Dihexa can be compounded for subcutaneous injection or intranasal administration, depending on your clinical profile and goals. Nasal administration allows for direct CNS delivery across the blood-brain barrier. Your prescribing clinician will specify the route, dose, and frequency as part of your individualized protocol.
How long before I notice results?
Some patients report early shifts in mental clarity within 2–3 weeks; more robust cognitive changes are typically observed over a 4–8 week course. Peptide therapy responses vary considerably by individual, baseline cognitive function, and indication. Your clinician will evaluate your progress at regular check-ins and adjust your protocol as needed.
Are there side effects?
Human clinical trial data for Dihexa is limited, so a complete safety profile in humans is not yet established. Mild effects reported by users include headache and nausea, particularly during initial dosing. Because Dihexa activates the HGF/c-Met pathway — which plays a role in certain cancer types — it is not prescribed to patients with a history of cancers involving c-Met dysregulation without specialist clearance. Your clinician will conduct a thorough review of your health history and medications before any prescription is issued.
Can I pause or cancel my subscription?
Yes. You can pause or cancel at any time through your TruVera patient portal — no phone calls, no cancellation fees. If you have questions about your protocol before canceling, your care team is always available to discuss adjustments.