Monthly
$169
/mo
Flexibility with month-to-month billing.
- Compounded LL-37 therapy
- Licensed clinician oversight
- Care-team messaging
- Free discreet shipping
Skip to product information
Start today
LL-37 Immune Support Therapy
LL-37 is an antimicrobial peptide studied for its role in immune defense and tissue repair. Truvera’s LL-37 Therapy is designed to support immune resilience and skin health under medical supervision.
Potential Benefits
- Supports immune defense
- Promotes skin and tissue health
- Encourages recovery and resilience
Short Version
An immune-focused peptide therapy designed to support the body’s natural defenses.
- US-licensed clinicians
- Licensed US pharmacies
- Prescription required
- Free discreet shipping
Peptide · Immune Support
Strengthen your immune resilience — with the peptide your body already makes.
LL-37 is the only known human cathelicidin antimicrobial peptide, produced naturally by immune cells and epithelial tissue. Prescribed by a licensed clinician, compounded to order, and shipped to your door.
- Activates innate immune defenses — your first line of protection against bacteria, viruses, and fungi
- Modulates both pro- and anti-inflammatory cytokines, helping calibrate immune responses without shutting them down
- Derived from a naturally occurring human peptide — supports immune function rather than suppressing it like steroids
How it works
Your LL-37 therapy journey in 4 steps
From online intake to medication delivered — in as little as 3 days.
-
Complete your online intake
A 5-minute medical intake covers your health history, current immune concerns, medications, and wellness goals. No appointment needed.
-
Clinician review
A licensed US clinician reviews your intake and, if clinically appropriate, issues your LL-37 prescription and compounding order.
-
Medication ships free
Your LL-37 is compounded at a licensed US pharmacy and shipped in discreet, temperature-controlled packaging.
-
Ongoing care
Message your care team anytime. We monitor your immune response and adjust your protocol at every check-in.
Pricing
Transparent LL-37 program pricing.
One monthly price covers your clinician visits, compounded medication, shipping, and care team access.
Most popular
Quarterly
$139
/mo
Save 17% vs monthly
Best balance of savings and commitment.
- Everything in Monthly
- Billed quarterly
- Priority clinician response
- Quarterly immune review
Annual
$119
/mo
Save 30% vs monthly
Our best price for long-term immune support.
- Everything in Quarterly
- Billed annually
- Dedicated care coordination
- Annual protocol review
LL-37 is a compounded peptide, not an FDA-approved drug. Prescriptions are issued only at the discretion of licensed clinicians and only when medically appropriate.
Eligibility
Is LL-37 right for you?
You may be a candidate if:
- You experience frequent infections, prolonged illness recovery, or want to support a weakened immune system
- You have a chronic inflammatory or autoimmune condition and are seeking immune modulation support
- You are 18+ and can complete required intake and follow-up monitoring
- You are seeking a clinician-supervised peptide approach to immune resilience
Not right for you if:
- You are pregnant, trying to conceive, or breastfeeding
- You have a current or prior cancer diagnosis (clinician review required)
- You have an active, serious systemic infection requiring urgent medical care
- You take immunosuppressant medications without clearance from your prescribing physician
What is LL-37?
The science behind LL-37.
LL-37 is the only known human cathelicidin — a 37-amino acid peptide produced naturally by neutrophils, macrophages, mast cells, and epithelial cells lining the skin, lungs, and gut. It is named for the two leucine residues at its N-terminus and its total length of 37 amino acids. Unlike synthetic antimicrobial agents, LL-37 evolved as part of the innate immune system: it disrupts microbial membranes directly and simultaneously orchestrates the adaptive immune response, bridging both arms of immunity in a single molecule.
LL-37's mechanisms are broad and well-documented in peer-reviewed literature. It kills gram-positive and gram-negative bacteria, certain enveloped viruses, and fungi by embedding in and disrupting pathogen lipid bilayers — a physical mechanism that is difficult for microbes to develop resistance to. Beyond direct microbial killing, LL-37 acts as an immunomodulator: it promotes dendritic cell maturation, recruits neutrophils and monocytes to infection sites, regulates TLR (toll-like receptor) signaling, and stimulates angiogenesis and wound repair through keratinocyte migration. Research published in journals including Antimicrobial Agents and Chemotherapy, Journal of Immunology, and Nature Immunology has characterized these roles extensively.
Deficiencies in LL-37 expression have been linked to increased susceptibility to respiratory infections, skin conditions such as atopic dermatitis and rosacea, and impaired wound healing. Conversely, some inflammatory conditions involve dysregulated upregulation of LL-37. The clinical application of exogenous LL-37 — delivered as a compounded peptide — aims to supplement endogenous levels in patients whose immune defenses may benefit from additional support. LL-37 has not completed human clinical trials as a standalone approved therapeutic and is available through licensed clinicians via Section 503A compounding pharmacies.
Patient experience
Care that feels clear from day one.
"I was getting sick four or five times a year and each illness dragged on for weeks. After three months on LL-37 my recovery times are noticeably shorter and I've only had one minor cold. The intake process was thorough and my clinician took the time to explain what the peptide actually does."
Verified patient
Immune resilience
"My functional medicine doctor mentioned LL-37 but couldn't prescribe it directly. TruVera made the process easy — the clinician reviewed my labs and history, and I had my first supply within a week. My energy during what would normally be my sick season has been much better."
Verified patient
Seasonal immune support
"I appreciated that TruVera was transparent that this is a compounded peptide and not a cure-all. The care team has been responsive and we've adjusted my dose based on how I was responding. I feel like I have actual support, not just a product being sold to me."
Verified patient
Care team support
FAQ
LL-37 therapy questions
What exactly is LL-37 and is it FDA-approved?
LL-37 is the only known human cathelicidin antimicrobial peptide — a 37-amino acid peptide produced naturally by immune and epithelial cells to defend against infection and coordinate immune responses. It is not FDA-approved as a standalone drug. TruVera provides LL-37 through licensed compounding pharmacies under Section 503A of the Federal Food, Drug, and Cosmetic Act — available only with a valid prescription from a licensed clinician.
What conditions is LL-37 used for?
Clinical interest in LL-37 centers on conditions where immune defense and regulation are suboptimal, including recurrent infections, chronic respiratory illness, impaired wound healing, and skin conditions such as atopic dermatitis and rosacea that are associated with reduced cathelicidin expression. It has also been studied for its role in gut mucosal immunity. A clinician will determine whether LL-37 is appropriate for your specific situation based on your health history and current symptoms.
How is LL-37 administered?
LL-37 is most commonly compounded for subcutaneous injection, which allows systemic distribution and is the best-characterized route in research settings. Some compounding pharmacies also prepare intranasal or nebulized formulations for respiratory applications. Your care team will specify the dose, concentration, and route of administration based on your clinical needs during your consultation.
How long before I notice results?
Some patients report feeling more resilient within the first few weeks; meaningful changes in infection frequency or recovery time are typically assessed over 8–12 weeks of consistent use. Immune modulation responses vary considerably by individual, baseline immune status, and indication. Your clinician will evaluate your progress at regular check-ins and adjust your protocol accordingly.
Are there side effects?
LL-37 is a naturally occurring human peptide, and compounded formulations generally have a favorable tolerability profile in clinical use. The most commonly reported effects are temporary injection-site reactions such as mild redness or local discomfort. Because LL-37 also has immunomodulatory properties, it is used with caution in patients with active autoimmune conditions or complex immune histories. Long-term human safety data from controlled trials is limited. Your clinician will review your full health history before prescribing.
Can I pause or cancel my subscription?
Yes. You can pause or cancel at any time through your TruVera patient portal — no phone calls, no cancellation fees. If you have questions about your protocol before canceling, your care team is always available to discuss adjustments.